Principal Engineer (Site Reliability / SRE) - #1660599
Genomics England

Genomics England partners with the NHS to provide whole genome sequencing diagnostics. We also equip researchers to find the causes of disease and develop new treatments – with patients and participants at the heart of it all.
Our mission is to continue refining, scaling, and evolving our ability to enable others to deliver genomic healthcare and conduct genomic research.
We are accelerating our impact and working with patients, doctors, scientists, government and industry to improve genomic testing, and help researchers access the health data and technology they need to make new medical discoveries and create more effective, targeted medicines for everybody.
Job DescriptionAre you passionate about helping to mature technical practices and empowering teams to run resilient and reliable services? At Genomics England we are looking for a Principal Site Reliability Engineer to help lead and refocus our small SRE capability, ultimately growing it to become thought-leaders in system reliability across the organisation.
About the Role
As the Principal Site Reliability Engineer, you will be a hands-on contributor with exemplary platform engineering skills, who also has an ability to lead and think strategically to identify and prioritise areas with the greatest impact. You may have previously worked in a variety or roles and job titles within engineering, and you may have worked in a variety of organisational contexts. Whatever your past experience, it will have given you a deep understanding of SRE principles and practices and how these are used to build and operate reliable services that exceed customer expectations.
You will be a problem-solver who identifies risks, issues, gaps, and dependencies and brings people together to find solutions. You will do this through your supportive, empathetic and collaborative behaviours - acting as coach, mentor, guide or constructive questioner as the situation demands. You are pragmatic but also mindful of the big picture - consciously balancing the immediate goals of teams against the long-term direction for their products. You will be a great communicator, comfortable not just leading your own team, but also engaging across the engineering community and with non-technical stakeholders.
About the Tech Stack
The SRE team will support squads that run a variety of services: most of these are either user-facing web applications (React), backend APIs (Python), bioinformatics pipelines (NextFlow), or data ETL workflows (Prefect, Dremio). These services increasingly run in AWS, though there is still a significant on-premise presence, and they run in a mixture of compute environments, from ECS/Fargate to HPC clusters to (occasionally) Kubernetes.
Within the SDLC we have a standard toolchain which includes Terraform for infrastructure-as-code, GitLab for source code and CI/CD, Artifactory for software artefacts, and DataDog for observability. We are working to become interoperable with the wider NHS via open standards like FHIR and GA4GH APIs and increasingly aiming to integrate with their own API Management platform.
Job Description
- Assess the current state of human and technical processes and practices from a site reliability perspective, and identify the areas of greatest concern
- Develop a roadmap of initiatives aimed at raising the maturity of live services through SRE practices (SLOs, Critical User Journeys, monitoring with Golden Signals, release-engineering etc.)
- Grow and lead a small team of Site Reliability Engineers to roll out those initiatives across the organisation through partnership with product squads
- Work with key stakeholders to establish and embed key SRE principles (e.g. Error Budget Policies)
- Maintain close contact with Engineering leadership and other "enabling" teams (Test Enablement, Developer Platform) to ensure that SRE work is fully aligned with our direction of travel
- Stay abreast of emerging technologies and industry trends, and incorporate them into our software development practices
- Contribute to the wider conversation at Genomics England and help mature our technical practices
Qualifications
While we recognise the value of relevant qualifications or certifications, we are primarily interested in your real-world experience.
Essential Skills and Experience
- Comprehensive knowledge of SRE principles and practices with significant experience of applying these to real-world situations
- Excellent software engineering skills especially in the context of release automation and other toil-eliminating activities (Python preferred, polyglot ideal)
- Strong understanding of how architecture and other factors contribute to the overall resilience of systems
- Extensive experience of platform engineering across CI/CD, Infrastructure as Code, operational monitoring and alerting, backup and recovery etc.
- Experience in at least one major public cloud (AWS preferred but not essential)
- Demonstrable ability to lead teams, manage, direct, mentor and plan work
- Strong interpersonal skills with a temperament that builds trust and connection within and across squads through open, honest communication
- Comfortable engaging responsively with teams both remotely and in person when required
- Ability to navigate rapidly to effective solutions through engaged and inclusive listening, clarity of thought, clear documentation, and succinct presentation
Desirable Experience
These skills are not essential but if you have either of them they may prove to be useful:
- Background in healthcare or bioinformatics
- Experience in regulated environments
If you’re an experienced Site Reliability Engineer leader, who thrives on working collaboratively to mature engineering practices, we’d love to hear from you. Join us at Genomics England and make a meaningful impact in the world of genomics.
QualificationsWhile we recognise the value of relevant qualifications or certifications, we are primarily interested in your real-world experience.
Additional InformationSalary: £103,500Being an integral part of such a meaningful mission is extremely rewarding in itself, but in order to support our people, we’re continually improving our benefits package. We pride ourselves on investing in our people and supporting them to achieve their career goals, as well as offering a benefits package including:
- Generous Leave: 30 days’ holiday plus bank holidays, additional leave for long service, and the option to apply for up to 30 days of remote working abroad annually (approval required).
- Family-Friendly: Blended working arrangements, flexible working, enhanced maternity, paternity and shared parental leave benefits.
- Pension & Financial: Defined contribution pension (Genomics England double-matches up to 10%, however you can contribute more if you wish), Life Assurance (3x salary), and a Give As You Earn scheme.
- Learning & Development: Individual learning budgets, support for training and certifications, and reimbursement for one annual professional subscription (approval required).
- Recognition & Rewards: Employee recognition programme and referral scheme.
- Health & Wellbeing: Subsidised gym membership, a free Headspace account, and access to an Employee Assistance Programme, eye tests, flu jabs.
Equal opportunities and our commitment to a diverse and inclusive workplace
Genomics England is actively committed to providing and supporting an inclusive environment that promotes equity, diversity and inclusion best practice both within our community and in any other area where we have influence. We are proud of our diverse community where everyone can come to work and feel welcomed and treated with respect regardless of any disability, ethnicity, gender, gender identity, religion, sexual orientation, or social background.
Genomics England’s policies of non-discrimination and equity and will be applied fairly to all people, regardless of age, disability, gender identity or reassignment, marital or civil partnership status, being pregnant or recently becoming a parent, race, religion or beliefs, sex or sexual orientation, length of service, whether full or part-time or employed under a permanent or a fixed-term contract or any other relevant factor.
Genomics England does not tolerate any form of discrimination, harassment, victimisation or bullying at work. Such behaviour is contrary to our virtues, undermines our mission and core values and diminishes the dignity, respect and integrity of all parties. Our People policies outline our commitment to inclusivity.
We aim to remove barriers in our recruitment processes and to be flexible with our interview processes. Should you require any adjustments that may help you to fully participate in the recruitment process, we encourage you to discuss this with us.
Blended working model
Genomics England operates a blended working model as we know our people appreciate the flexibility that hybrid working can bring. We expect most people to come into the office a minimum of 2 times each month. However, this will vary according to role and will be agreed with your team leader. There is no expectation that people will return to the office full time unless they want to, however, some of our roles require full time on site attendance e.g., lab teams, reception team.
Our teams and squads have, and will continue to reflect on what works best for them to work together successfully and have the freedom to design working patterns to suit, beyond the minimum. Our office locations are: Canary Wharf, Cambridge and Leeds.
Onboarding background checks
As part of our recruitment process, all successful candidates are subject to a Standard Disclosure and Barring Service (DBS) check. We therefore require applicants to disclose any previous offences at point of application, as some unspent convictions may mean we are unable to proceed with your application due to the nature of our work in healthcare.
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